Programa de la primera jornada:
Epigenetics: Concept, Historical Perspective, Techniques and Applications
1. DNA chemical structure
2. Epigenetic changes: accessory chemical modifications of the DNA
3. History and concepts that influenced the Waddingtonian definition of Epigenetics: Preformation vs Epigenesis
4. The Waddingtonian concept of ‘Epigenetics’
5. Known mechanisms of epigenetic modification:
i. DNA methylation/hydroxymethylation
ii. Histone modifications
iii. Chromatin rearrangements
iv. Small RNA action
6. Techniques to measure change in DNA methylation:
i. Restriction enzymes
ii. Bisulphite sequencing
iii. Methylated DNA Immunoprecipitation (MeDIP)
iv. High-throughput sequencing techniques
7. Epigenetic applications and implications:
i. Developmental Origin of Diseases (Barker Hypothesis)
ii. Environmental Epigenetics
iii. Transgenerational Epigenetics
iv. Role of Epigenetics in Evolutionary Biology
Siga la transmisión en vivo {urltx umce-entomologia}
Fecha: Miércoles 5 de diciembre, de 17:30 a 19:30 horas.
Lugar: Transmisión desde la UMCE